Shared genetic architecture between COVID-19 severity and other health conditions

Shared genetic architecture between COVID-19 severity and other health conditions
Researchers in the United States have identified a shared genetic architecture between coronavirus disease 2019 (COVID-19) severity and other health conditions.
Using electronic health record data and genomic data from Veteran Affairs (VA), the Million Veteran Program (MVP), and the United Kingdom Biobank (UKBB), the team identified conditions associated with risk factors for severe COVID-19.
The study found that phenotypes associated with poor COVID-19 outcomes such as thrombotic complications also shared genetic variants associated with severe COVID-19.
Among respiratory conditions, only idiopathic pulmonary fibrosis and asthma shared genetic risk factors with severe disease, with no association observed for chronic obstructive pulmonary disease.

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