Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer's

Researchers probe deeper into the neuronal mechanisms underlying olfactory dysfunction in Alzheimer’s
Loss of smell or olfactory dysfunction is an early indication of the neurodegenerative Alzheimer's disease (AD) and appears in approximately 90% of all patients. While loss of smell is a major symptom, patients with AD are only unable to recognize specific odors and do not completely lose their sense of smell; this suggests a possible region-specific involvement of the olfactive center in the brain.
Amyloid β (Aβ), a toxic protein that accumulates in the brain is a known contributing factor in AD pathogenesis and is also present in the olfactory system that controls the sense of smell. However, the pathology and mechanisms of AD-specific olfactory dysfunction involving olfactory sensory neurons (OSNs) remain unclear.

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Emily Henderson , Alzheimer Research , Professor Cheil Moon , Alzheimer 39s Disease , Brain , Diagnostic , Mouse Model , Neuron , Neurons , Pathology , Bph , Protein , Research , எமிலி ஹென்டர்சன் , முதுமறதி ஆராய்ச்சி , மூளை , கண்டறியும் , சுட்டி மாதிரி , நரம்பியல் , நோயியல் , பீயெச் , ப்ரோடீந் , ஆராய்ச்சி ,