<p>Tuberculosis, caused by the bacterium <em>Mycobacterium tuberculosis</em> (Mtb) kills upwards of 1.6 million people a year, making it one of the leading causes of death by an infectious agent worldwide—and that number is only growing larger. How, exactly, Mtb evades the immune system isn’t yet known, but a collaborative team of researchers from the University of Massachusetts Amherst and Seattle Children’s Research Institute recently discovered something surprising: prior exposure to a genus of bacteria called <em>Mycobacterium</em> seems to remodel the first-line defenders in the body’s immune system. Furthermore, how those cells are remodeled depends on exactly how the body is exposed. These results, published recently in <a href="https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011871"><em>PLOS Pathogens</em></a><em>,</em> suggest that a more integrated treatment approach that targets all aspects of the immune response could be a more effective strategy in the fight against tuberculosis.</p>
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,Daegan Miller ,Kevin Urdahl ,Alissa Rothchild ,Seattle Children Research Instituteand ,Animal Sciences Department ,National Institute Of Allergy ,National Institutes Of Health ,Seattle Children Research Institute ,University Of Massachusetts Amherst ,Massachusetts Amherst ,Seattle Children ,Research Institute ,Trojan Horse ,Dat Mai ,Research Instituteand ,National Institutes ,National Institute ,Infectious Disease ,Immune Mechanisms ,Protection Against Mycobacterium ,
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