Real-world evidence SARS-CoV-2 mRNA vaccines work and help prevent worst outcomes
Researchers in the United States have conducted a study demonstrating the real-world effectiveness of the Pfizer-BioNTech BNT162b2 and Moderna mRNA-1273 vaccines at preventing hospitalizations due to coronavirus disease 2019 (COVID-19).
The prospective observational case-control study showed that the vaccines were approximately 87% effective at preventing COVID-19 hospitalizations.
The study was conducted by the “Influenza and Other Viruses in the Acutely Ill (IVY) Network” at 18 geographically dispersed sites across the US during the early phase of the vaccination program.
“The vaccines were highly effective at preventing COVID-19 hospitalizations among adults in March through May 2021,” writes Wesley Self from Vanderbilt University Medical Center in Nashville and colleagues.