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That a high dosage of adenovirus in the bloodstream could lead to clotting, low levels of platelets and antibodies to platelets was known 20 years ago from animal studies in gene therapy.
Norwegian biologist Gro Amdam writes this in an email to ScienceNorway from the U.S., where she is professor at Arizona State University.
"Studies on animals showed this — in experiments on monkeys, rabbits and mice. The problem became an obstacle for research and development of gene therapy," Amdam writes.
The AstraZeneca vaccine against COVID uses a so-called adenoviral vector to deliver the vaccine in our bodies.

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