Personalized Neoantigen Vaccine Induces Continued Responses in Pretreated, Advanced HCC

Intradermal injection with GNOS-PV02 plus plasmid-encoded interleukin-12 followed by electroporation elicited complete molecular response detected via circulating tumor DNA in 4 additional patients as second-line therapy in patients with advanced hepatocellular carcinoma.

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New Zealand ,Auckland ,Barcelona ,Comunidad Autonoma De Cataluna ,Spain ,Niranjan Sardesai ,Ted Gane ,University Of Auckland ,New Zealand Liver Unit ,Auckland City Hospital ,Barcelona Clinic Liver Cancer ,Gnos Pv02 Plus Plasmid Encoded Interleukin 12 ,Patients With Advanced Hepatocellular Carcinoma ,Gt 30 Study ,Nct04251117 ,Sbchb ,D ,Racp ,Mnzm ,Phd ,Geneos ,