The University of Wollongong (UOW) cosmogenic 10Be and 26Al sample preparation laboratory has been in operation since the start of 2017. As primarily a feeder laboratory to ANSTO's Centre for Accelerator Science, our sample preparation procedures have been optimised with consideration to the setup of ANSTO's 6MV SIRIUS accelerator, and aim to achieve a balance between sample throughput as well as Be and Al target purity. A comparatively small number of samples (n = 68) have also been prepared for measurement at the Australian National University 14UD accelerator. 10Be/9Be ratios of procedural blanks measured on SIRIUS have fluctuated over time with the median for the year 2017 being 5.16 × 10−16 (IQR = 4.11 × 10−16 to 7.16 × 10−16, n = 18), increasing to 1.62 × 10−15 (IQR = 1.05 × 10−15 to 2.17 × 10−15, n = 31) for 2018 and 2019, a period coinciding with elevated boron levels in our samples, and finally decreasing to 1.15 × 10−15 (IQR = 8.63 × 10−16 to 1.60 × 10−15, n = 34) for 2020 and 2021. In contrast, 26Al/27Al ratios of procedural blanks measured on SIRIUS have shown a slight but continuous improvement over time with the median for 2017 of 1.70 × 10−15 (IQR = 8.19 × 10−16 to 5.25 × 10−15, n = 12) decreasing to 1.07 × 10−15 (IQR = 8.5 × 10−16 to 1.53 × 10−15, n = 13) for 2021. Median 10Be/9Be relative uncertainty of procedural blanks analysed on SIRIUS is 18 % (IQR = 15 % to 22 %; n = 86) whereas the median 26Al/27Al relative uncertainty of procedural blanks is higher at 60 % (IQR = 41 % to 100 %; n = 56), statistic resulting from most blanks yielding low 26Al counts (median = 2; IQR = 1–4.5). Average 9BeO− output relative to standard is between ∼ 70 % – 80 % for samples analysed on SIRIUS (n = 895) and ∼ 130 % for samples analysed at ANU (n = 68). 27Al− output relative to standard is lower for samples pressed into cathodes at UOW (∼60 %, n = 432) and analysed on SIRIUS than for those pressed at ANSTO (∼90 %, n = 119). Average 27Al− output relative to standard for samples analysed at ANU is ∼ 80 % (n = 62). 10Be and 26Al measurements of various laboratory intercomparison materials prepared at UOW between 2017 and 2022