After a fifth COVID-19 wave, driven by the new omicron variants, burned through South Africa, the infections are now spreading in Europe. Are the BA.4 and BA.5 more contagious? Do vaccines work against the BA.4 and BA.5 variants? Is the FDA going to approve new vaccines? What happened with omicron subvariants in South Africa? Where have the BA.4 and BA.5 spread to? What is happening with COVID-19 in Portugal?