No Biopsy Needed to Accurately Diagnose Celiac Disease in Nearly All Adults
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In a potentially game-changing move, new research supports the elimination of biopsy in the diagnosis of most cases of adult celiac disease, in favor of the no-biopsy approach.
However, this approach has not yet been widely adopted into clinical practice for diagnosing adults, mainly due to a limited international multi-center data, and testing in groups with low celiac disease rates. New research confirms that most adults do not require a biopsy for a reliable celiac disease diagnosis. A recent study by a team of researchers showed that a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels has high predictive capacity and diagnostic reliability for detecting small intestinal injury diagnostic of celiac disease in adults.