New Therapy for Parasitic Disease may Help Fight Coronavirus

New Therapy for Parasitic Disease may Help Fight Coronavirus
by Angela Mohan on 
April 5, 2021 at 8:26 PM
SARS-CoV-2, the coronavirus that causes COVID-19, can't dock on and infect human cells unless a human enzyme called cathepsin L cleaves the virus' spike protein.
Trypanosoma cruzi, the parasite that produce an enzyme called cruzain, helps them to replicate in humans. McKerrow's research team started looking for inhibitors of cruzain. One particularly effective cruzain inhibitor is called K777.
They later found that cathepsin L looks and acts like cruzain.
In a study published by
ACS Chemical Biology, McKerrow and the team show that low concentrations of K777 inhibit cathepsin L can reduce SARS-CoV-2's ability to infect four host cell lines, without harming the cells.

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