Advanced Peptide Synthesis Program Uses Predictive Modeling and Simulation Tools to Shorten Peptide Process Development
The field of Solid Phase Peptide Synthesis (SPPS) has boomed over the last few decades. But many companies are still relying on procedures used in the laboratory to achieve large-scale production. This has proven to be inefficient and not cost-effective. Not surprisingly, the overall quest to produce high-quality peptides at lower costs while meeting customers’ expectations for issues like cutting solvent consumption (and reducing environmental impact) without affecting the product quality has intensified.
Pharmaceutical manufacturers expect their CMDOs to deliver an efficient, yet robust and cost-optimized process for producing the final product. But a trial-and-error strategy that pushes the development of an optimal process later is not the most effective approach.