Additionally, in moderate or severe diseases at high risk of progression, Remdesivir may be considered for up to five days. It should be started within 10 days of onset of symptoms in those having moderate to severe disease with a high risk of progression (requiring supplemental oxygen) but who are not on IMV or ECMO. �� New COVID-19 Guidelines: Antibiotics Shouldn't Be Used in COVID-19 Unless Suspicion of Bacterial Infection, Says Central Govt.