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DUBLIN, May 19, 2021 /PRNewswire/ -- Nemysis Ltd today announced the issuance of Canada Patent Number 2,852,365 entitled "Proteases able to hydrolyse gluten peptides and proteins at acid pH, from the Actinomycete Actinoallomurus". This is the first patent issued to Nemysis in Canada in the field of Celiac Disease (CeD) and management of Gluten Intolerance.
The patent covers five novel Endoproteases and related sequences discovered in a soil Actinoallomurus strain and useful to produce enzymatic compositions either as a mixture or as single ingredients. The patented Endoproteases belong to the S8/S53 family of subtilisin kexin sedolisins, effective in cleaving the immunogenic epitopes of gliadin at pH between 3 and 8. The invention also includes methods for the recombinant production of the enzymatic compositions in several cell hosts. The patented enzymatic compositions are helpful for the treatment and/or prevention of Celiac Disease, dermatitis herpetiformis and any other disorder associated with gluten intolerance or sensitivity.