Emily Sanderson received the vaccine at the Sheffield Arena vaccination centre.
Ms Sanderson, who has an underlying health condition, was due to receive the AstraZeneca vaccine, but this was changed to Moderna, the NHS said.
The first Moderna jabs will be delivered in England today, as the NHS vaccination programme reaches another milestone.
If you've not had it yet and you're in an eligible group, you can still get your free #NHSCOVIDVaccine. https://t.co/IvtY3Ca2Mxpic.twitter.com/zLVDC9ULGQ
It comes after UK regulators said that people under the age of 30 should be offered an alternative to the AstraZeneca vaccine, saying there was a possible link between the jab and “extremely rare” blood clots.