Are you ready for a little March Madness?
As always, let's kick this off with just how difficult it is for a low seed to make a run in NCAA Tournament betting: Only one 16-seed has ever knocked off a No. 1 seed in the opening round, nine teams seeded 13th or worse have survived the opening weekend as March Madness picks, and just one team seeded No. 12 or lower has lasted to the Elite Eight.
As for the famed Final Four? Only five double-digit seeds - most recently Loyola-Chicago as a No. 11 in 2018 - have ever made it that far.