Hypertension (high blood pressure, or HBP) is one of the primary catalysts behind stroke and heart disease. Losartan (brand name: Cozaar) and lisinopril (brand name: Zestril) are first-line antihypertensive drugs that control HBP. Lisinopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) that inhibits enzyme conversion that raises blood pressure.