The home boss had earlier said the government would actively consider the plea on humanitarian grounds.
"The law ministry has informed us that Khaleda Zia cannot go abroad unless her sentence is commuted. In the light of this, the application of Khaleda Zia's family will not be granted," Asaduzzaman said at his Secretariat office yesterday.
He also said they would soon inform the BNP chief's family of their decision.
The minister mentioned that Prime Minister Sheikh Hasina gave Khaleda the opportunity to receive treatment at home at her convenience following suspension of her sentence on humanitarian grounds.
Khaleda later got infected with Covid-19 and was admitted to Evercare Hospital in the capital, he said.