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The story’s MacGuffin is the mysterious “Tears of the Moon,” the petals of an Amazonian tree that can supposedly heal any illness. Fulfilling the Rachel Weisz and Brendan Fraser roles (or should that be Humphrey Bogart and Katharine Hepburn? Harrison Ford and Karen Allen?) are Lily Houghton (Blunt), a doctor whose professional know-how and penchant for wearing pants put her at odds with the patriarchal systems of her World War I era, and Frank Wolff (Johnson), a riverboat captain who loves cracking dad jokes and pulling small cons on the people around him. Also along for the ride is Lily’s brother MacGregor (Jack Whitehall), who prefers a life of leisure and finds the prospect of exploring the Amazon horrifying. Of course, they aren’t the only people seeking this particular holy grail—Prince Joachim (Jesse Plemons), a German aristocrat, seeks the petals as a means toward (what else?) world domination, and has recruited a group of undead conquistadors, led by Aguirre (Édgar Ramirez), to help him.