Prime minister Sylvestre Ilunga lost a no confidence vote in parliament, and subsequently resigned on Friday.
Analysts have said that the dismissal of Ilunga means that President Felix Tshisekedi has effectively cut any political links he had left with former leader Joseph Kabila's Common Front for Congo (FCC) party.
"His removal from office confirms above all the reversal of the balance of power that has been observed for several months now between former President Joseph Kabila and the new Felix Tshisekedi", said Trésor Kibangula, an analyst at the Congo Study Group.
Tshisekedi, who entered the alliance at his controversial election in late 2018, has accused allies of Kabila of seeking to undermine his rule. He says they have severally frustrated his reform program.