Mooney singled out Matthews in the segment, joking of her oyster scandal: "This bird can go and get shucked!"
But Matthews has responded with a slapdown which poured disdain on Mooney's Triple M show and called him out for bullying.
Uploading a photo of the comedian with a pig emoji over his face, Matthews wrote to her 219,000 followers: "Someone just sent me this and I'm utterly gobsmacked. It really does go to show how low the human race is.
Ruby Tuesday Matthews set her followers on the radio host. Picture: Instagram.
"If all you can do is completely right (sic) off a single mum to make a segment, what do you really have going for yourself and your D grade radio show."