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Each one-unit increase on a disease activity score during the first year after enrollment into a systemic lupus erythematosus (SLE) cohort was associated with a significant increased risk for death and organ damage during subsequent follow-up, researchers reported.
On a multivariable analysis, a one-unit increase on the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) version of the SLE Disease Activity Index (SLEDAI) was associated with a 22% higher risk of death during an average 7 years of follow-up (HR 1.22, 95% CI 1.13-1.32,
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