The publisher has not yet confirmed how many redundancies are being made as a consultation process remains ongoing until the end of the month.
Press Gazette has reported that 16 of 29 full-time London-based news staff had been told their jobs were at risk, with four roles thought to be available for those 16.
Brammar announced on Thursday that she had been offered a reduced editor role running the website, but said “news is at the heart of what Huffpost was for me. So I am bowing out”.
In a message to staff she said it was time to “step back to let the new leadership get to work”.