Variety, Global Citizen CEO Hugh Evan teased of the show, "I can tell you that J.Lo has a huge surprise in store, and I can tell you that H.E.R. is planning something super, super cool, involving hundreds of other people as well, which is really exciting."
Lopez brings her mother Guadalupe Rodríguez out on stage to sing "Sweet Caroline," while Foo Fighters are joined by
Also making appearances throughout "VAX Live: The Concert to Reunite the World" are Prince Harry, Ben Affleck, Chrissy Teigen, Jimmy Kimmel, Sean Penn and David Letterman, as well as First Lady Dr. Jill Biden and Vice President Kamala Harris.