Both occurred on US 50 near milepost 21, in Scioto Township.
The first was a motorcycle crash that took place at approximately 9:45 p.m, when a 2010 Harley-Davidson Sportster, operated by Chase Rutherford, 34, of Chillicothe, was traveling southeast on US 50 as it negotiated a curve.
Rutherford lost control of the motorcycle, slid off the right side of the roadway, and struck a guardrail, according to a news release.
Rutherford was not wearing a helmet at the time of the crash and was transported by Scioto Township EMS to Adena Regional Medical Center. He was later flown to Grant Medical Center in serious condition.