Former Taoiseach Enda Kenny will join Ryan ahead of his role in a new show starting next week, which sees him rediscovering Ireland's railway routes.
Broadcaster Sarah McInerney, recently announced as one of the new presenters of Prime Time, will chat about her new role, taking those in power to task and how she ended up presenting a whole radio show on her mobile phone.
Paul Howard, journalist and author of 23 books featuring Ross O' Carroll Kelly, will be on the show to discuss everything from class privilege in Ireland to how rock is surviving the pandemic, while a group of parents and children who are living with autism and the everyday challenges they face will also be on the show to mark World Autism Awareness Day.