An exact closing date has not been confirmed but it will be in August.
The news comes as Hanley is losing its large Debenhams branch in the Potteries Shopping Centre.
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Stoke-on-Trent Live readers have been giving their views on what could possibly replace M&S - but many say they feel it is 'irreplaceable' and took to our Facebook page to praise the staff at the branch.
Looking to the future, other readers noted the sheer size of the store and suggestions range from trying to tempt the likes of Zara and John Lewis to the city centre to dividing the space up to form a destination for a number of independent shops similar to Affleck's Palace in Manchester.