East Renfrewshire councillors have approved Westpoint Homes’ proposal for the old Eastwoodhill Eventide home on Fenwick Road.
The listed building will be turned into four flats, with 52 more homes built on the site.
Unlisted buildings and an extension to the ex-care home can be demolished.
Councillor Betty Cunningham welcomed the scheme, which she hoped would stop young people using the site as a “drinking den”.
“I know people have spoken to me about the problem of young ones going in there at night,” she said.
“I was quite glad to see it coming forward. If it’s getting developed, then they certainly won’t be using it as a drinking den.”