May 25, 2021
With all events adjudicated, intensive blood pressure-lowering remains superior to standard control when it comes to reducing adverse clinical outcomes in nondiabetic patients at high cardiovascular risk, with that benefit accompanied by higher risks of some serious adverse events, including hypotension, electrolyte abnormalities, acute kidney injury/failure, and syncope, final results of the SPRINT trial show.
When the initial trial results were released in November 2015, investigators had not yet been able to adjudicate all potential outcome events that occurred during the intervention period because the study was stopped early. In addition, they had not yet collected or analyzed data after the intervention period ended.