Over the past year, it has been quite challenging to predict with certainty what will happen to the current pandemic. However, it has become clear that SARS-CoV-2 is here to stay for at least a few more years. While it is likely that the disease will persist, I would not worry yet. Over time, we may end up with a situation similar to the flu or the common cold. It is indeed now quite clear that the virus can mutate and escape some of the immunity generated by prior infections and/or vaccines. Scientists and health care workers will have to remain extremely vigilant, monitor virus evolution and most likely update their vaccine designs on a regular basis. There are still many scientific questions that remained unanswered. One of the most important one will be to find out how long it will take to lose immunity after infection or vaccination. Ultimately, we want to maintain a situation in which the disease is less severe for life to return to normal.