Unless cures are found, Alzheimer's dementia is projected to affect nearly 13 million Americans by 2050-;overwhelming families, caregivers and our healthcare system. Yet only one new therapeutic, aducanumab, has come to market in the past 20 years, and therapeutic progress remains hampered for several reasons: recruiting study participants in clinical trials for Alzheimer's is more challenging than other disease areas, the trials take longer to complete and they are more costly.