Expansion Sequencing Creates Google Map of Mouse Brain Messages
Source: Shahar Alon, Daniel Goodwin, Ed Boyden
February 1, 2021
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“We now have a ‘Google map’ that allows measuring millions of RNA molecules within the tissue with nanoscale precision, without having to extract them as we did previously,” says Shahar Alon, PhD, of Bar-Ilan University’s Faculty of Engineering, Multidisciplinary Brain Research Center and Institute of Nanotechnology and Advanced Materials. The new technology, Expansion Sequencing or ExSeq, is a significant step forward in efforts to treat complex diseases, such as Alzheimer’s and cancer.
Science, researchers from Bar-Ilan University, Harvard University, and the Massachusetts Institute of Technology (MIT) reveal that they have succeeded in developing a technology that allows them, for the first time, to pinpoint millions of RNA molecules inside tissues with nanoscale resolution.