Iwuala who made his Super Eagles debut against Sierra Leone in March, missed the first-leg in Cairo due to fitness issues.
With the score 1-1, coach Osho immediately opted for fresh legs after the break as the People’s Elephants chased three goals to turn the encounter around.
Six minutes into the second-half, Augustine Oladapo, Gabriel Orok and Nabil Yarou were thrown into the fray to replace Philip Ozor, Victor Mbaoma and Nelson Ogbonnaya respectively.
Enyimba continued their push for more goals but Egypt goalkeeper Ahmed El Shenawy was brilliant between the sticks as he stopped two attempts from Orok to keep the visitors in control of the game.