EAU 2021: Radiotherapy After Radical Prostatectomy in the PSMA-PET Era
(UroToday.com) At the controversies in Onco-Urology session of the European Association of Urology 2021 annual meeting, Dr. Alberto Bossi discussed radiotherapy after radical prostatectomy in the PSMA-PET era. Adjuvant radiotherapy is defined as immediate postoperative radiation in the case of extraprostatic extension, positive margins, seminal vesicle infiltration, high Gleason score, or pN+ disease. Salvage radiotherapy is defined as a wait-and-see policy in that radiation is only given in the case of a rising postoperative PSA.
The ARTISTIC meta-analysis was published in 2020, combining data from RADICALS, GETUG-AFU 17, and RAVES showing no difference in PSA-driven event-free survival with a hazard ratio of 1.12 (95% CI 0.88-1.42), and a potential absolute difference of 1% at 5-years in favor of early salvage radiotherapy