The nicholas gwen blog is a molecular biologist and best selling populace science all of his work led into a very big question. What are the positives of something that isnt itself spot for us . If you have something that we humans created like a building or a call and watch, the more you use it, the more one down it gets and then the less functionality. So you can say that the car age is su, use it. But you know, biological organisms are different because when we stress also is when we use our bodies, we do get this damage. But then we can also repair also. So that means the damage then get turned into becoming stronger. In the end, the scientific term is derived from the ancient greek full to excite. For me says, basically how mesa is string through adversity, getting stronger from stress and becoming more resilient as you actually damage yourself. And home is this a companys us throughout our entire lives, beginning with the immune system early childhood. These hospital incubators, a temporary home for extremely vulnerable babies. The technicians are checking the ventilation, is nothing in only a minimal amount of particles to the premature baby. Bored at the same time, this is not supposed to be a gym, free environment, shooting infants, some old like tyria is counter productive and pointing them down to st. Louis team. You know, these are basically in this phase, the immune system learns how to fight infectious agents from outside when and that is the reason why we dont get sick. So often in our teens and in adulthood, approximately ive had no confidence on how does that look . The a nate immune system with bowman has a built in response protocol. It targets anything that identifies is a danger and only knows one way to fight. In contrast, the adaptive immune system to relate to require individually is custom trained, developing sophisticated Defense Mechanisms of the facing challenges in the shape of viruses. All bacteria. A whole nice effect. Stress leading to great to resilience and excessively Clean Environment presents the risk of the immune system. Basically, having Nothing Better to do instead of sites on our own body. Among the potential consequences or allergies. The Children Play outside and get dirty on the other hand makes them tougher on strengthens there. I mean fences thats according to the hygiene hypothesis. At least, traditionally a popular premise among home uses researchers. These days, the theory is considered too simplistic, but the principle has not been refuted. Nicholas spent bog dug around in a range of studies on the subject side of the positive factors. Include experiments with toxic comp tells that taking the moderation hudson the astonishing effects when you read studies, for instance, taking wins and then feeding them, wed kilo another person. And then youll see that if you keep it at a low dose, these ones will actually live longer than the ones that have not been placed on that or a, or thats examples with radioactive radiation. While you take, for instance, mice and then you, you read them. And of course, if you have really, really and height, i radiation, they get cans and die. But if you have a low level of activity live longer than the mice that has just been left alone on, how does this work . High doses of radiation, obviously by being coach the generation of free radicals through oxidation. They destroyed cells and cause whats called oxidative stress. But in smaller doses, radiation can reverse that process. In this case, free radical service and a look for the body to toughen up from that is home basis and effect of this kind do appear to occur in humans. Studies show the nicholas simmering Shipyard Workers hod longer than average life spends with some of the findings among radiologists in britain. While the results of the subject of considerable debate, diesel version effects do exist. The exact doses have yet to be determined. So dont try this at home kids assessment blog. What he would like to see is adding a little home uses to our everyday lives. Peer to exercises good view. It might mean a bit of damage to the body due to oxidative stress. But again, in the right dosage it makes it stronger. Plus, according to bind blog, the vegetarian diet can also have a whole mix. This effect. A lot of edible plants, in fact, have a slightly toxic effect for us due to water soluble molecules, they contain cold police steals. They stimulate the gene, the directs Defense Mechanisms at the cellular level, consumed in the right dosage. They helped to train our immune system. The this only works, however, if the city of the process is in our body, all functioning properly across the principal could like is the situation to a Waste Removal service. Once defective molecules have been detected by the cell that enclosed in a bubble. And how scenario a garbage truck which then heads off to a kind of recycling yard inside the cell. So molecular waste is then taken apart with many of the constituent elements being reused. This process a pre requisite for nice effect is called on top of g. Funding the right dosage, however, its far from straightforward. We can the 1st thing we can learn from home. This is just that biology is extremely complex. Its not just as straightforward as if youre trying to fix a car or Something Like that. When youre trying to do something on your body, thats always all of these feedback loops. So if you try to move your body in this direction, it will push back into the other direction. Then you can see even if damage yourself and well then you get stronger. But sometimes also when we then try somebody go so stronger, we end up in making ourselves riga in the end because of the systems as well. So we just learned that the body and just even the symbol when its really, really complex the, the bottom line, an unhealthy lifestyle isnt good for you. But now and again, a lot of us do like to, lets all head down. And muscle cells goes despite knowing that it can reduce our Life Expectancy and around half of us have an additional contributing factor that they can do little about that global Life Expectancy, cement is several years. Joseph and so women and i, s i a and his team in frankfort are among various researches hes been suspecting a 2nd culprit for many years. Now. The y chromosome is the one that genetically makes a man a man and struggles. I love to start to show us it is relatively clear from large scale studies that the y chromosome is indeed involved in this slightly lower Life Expectancy among men. The men of chromosomes store Genetic Information and our body cells. We have 23. 00 pads with one of them determining on gender. While women have 2 x chromosomes, men have an x and the y i suppose one was in fact the y chromosome is the smallest of all of our chromosomes and contains on the just over 50 genes, the x chromosome of 800. So it really is atanya chrome is im a cool way, was assume that its sold purposes to determine gen directed to determine me and that were such as have now come to conclude that the y chromosome plays a major role in male health. The problem is not the chromosome itself, but its low. Over the years and decades, someones y chromosome stops to deplete connection with errors and cell division. This affects what are called the blood stem cells and the bone marrow that building new blood cells. Some of them no longer have a y chromosome in either so form at the age of 45. 00 or so around 5 percent of man has suffered wide chromosome law. So its a slight 60, that figure is between 20 and 25 percent and fish on and among men, age 70 plus 40 percent. And todd y chromosome loves and photo specifics known chromosomes over a lifetime. Lots of the y chromosomes can lead to what scientists call a mosaic jews, the patch work of cells with different genetic compositions. This can have serious consequences. And then lets, since id like um, studies over the last 2 or 3 years, sufficient menus, lots of this y chromosome. I have a high likelihood of cardiovascular disease outside those diabetes. If its on the classic geriatric disease, Macular Degeneration taking up, which is a gradual loss of vision, these plans on the amount on to alcohol. So the question them was, how is this possible to become, to assign the team and frank for us, examine blood samples from patients with heart issues and found cells with no y chromosome fall more frequently. And this is the, this is the healthy group, and this is the group with cardiac, in sufficiency. And you can clearly see how y chromosome last is far more common in the group with cardiac and sufficiency. Another aspect is the patient slacking, the y chromosomes on average dice una from the heart condition. This is borne out and the survival statistics to patients with an artificial Hospital Research group in the us discovered the following. Among life, blood cells with alpha y chromosome can trigger a sickening or scarring in the hot, cold fibrosis. This stiffens up the hot, and compromises is capacity to pump. Its not yet clear whether these results can be applied to humans. The Frankfurt Team are observing a similar process and all cells, but there is still plenty of areas that have yet to be examined, including house account to the loss of the y chromosome. Depth side keep just the only really 2 recommendations at the moment. We know that smoking accelerates the loss of the y chromosome london man, so we recommend that men quits indicate answers to the 2nd thing that seems to be imaging. How is that the physical activity on a regular basis has a protective effect . Thats, thats of important key effect. The preventative action definitely always help, which is why the research is aim is to gain a more precise understanding of the harmful effects of y chromosome. Last, although even then, it will be many years until effective medication has been developed. So for the time being, the gap in Life Expectancy between men and women is set to stay the on the other hand, men often get a better deal in life. They dont go through child bus. Oh, have to go on the hill. This is only ever been available for women that, that might change in the near future. The, at the university of minnesota, a Research Team headed by going to guild of discover a compound that would be suitable for making known, hormonal contraceptive pills from men and micro. Were merely targeting a multitude of proteins, i would say probably about 6, and of course the, its very in stages of development. And the one that is the, for as long as the project on richard in the wake assets receptor, alpha. So i guess we are at the stage where we have um, i guess the clinic. Okay. I mean its not a candidate is called y c t 529. Im was tested on my own mice. This compound is reducing spar. Im counts. And the thoughts from montezuma and excite coal and the mouse is 35. 00. That is true. And so that is the amount of times that you have to administer the walk to see if the effect 99 percent of the mice rented, instead of tile 6 weeks after being taken off the drug they were able to reproduce again. Plus the side effects minimal. The contraceptive has since been tested on other animals the company that license the compound, they also did a similar amazing studies with rats. And they also found that it was equally effective. And also they did not see any side effect and then they actually also administer the talk to non human prime. Its basically its a monkeys. And again, it was effective and also totally reversible. Following those promising developments, the compound is now being tested in human Clinical Trials. Researches in gemini are also working on alternative contraceptive solutions biochemist claim and steve, born on his team at the university of fi, white up and conducting tests on mice and collaboration with american colleagues. The compound in this case is t d i 11861. It looks by inhibiting the enzymes soluble a little side place s a c plays an Important Role in activating spence and making the mo tile or able to swim. That means that and then thats it is prevents some swimming rapidly as in the, in effect from moving forward. It also stops the maturing process. So it isnt necessary for the store and the fumes with an egg. So hes midnight set up estimates the new compounds advantage is that it can take effect within just 30 minutes. And as a 100 percent, success rate of preventing fertilize ation for around 2 and a half hours. 24 hours after the injection, the much is spent, facility was restored before the Biology Research as move on to clinical studies. They want to make detailed improvements to t. D. I 11861 and produced optimize derivatives of the compound in the and the other compounds a more bio available, absorb, effective the word i just did it more slowly and work longer here. Its for our objective before starting Clinical Trials is to combine the features and also committing and if the results from the animal trials are confirmed in clinical studies with human subjects, non homeowner contraceptive pills cause mock another milestone in gender equality this way, perhaps soon well finally see a fair share of responsibility between men and women. For all potential consequences of romantic and couch. Let us read, why do you have this science question, then send it to us as a video, text or voice mail . If we answer it on the, i will send you a little surprise as that. Thank you. This weeks question comes from Bosnia Herzegovina specialist says, why is it that our teeth dont grow back from many people lisa teeth as they reach old age road route. Slight tempest isnt squirrels, have teeth that never stop growing. Whereas over the course of their lives, chunks produce ups of 40000 teeth whenever they lose one, a replacement 6 forward from behind the case only on nails in hand. Keep on growing. The only replacement for a loss to its an all substantial one, the to understand why we have to look at our tooth formation process or owed on to genesis, which begins in week 6 of pregnancy um milk p stone to form. At this point, the fetus is just 8 millimeters loan, starting in the 3rd or 4th month, the bugs of what will be all permanent teeth, appear in a secondary dental lamina. And once we have one, a milk teeth and wrapped in an average 8 months off the bus before floating else again between the ages of 6. 00 and 9. 00. The june now has sufficient space for the permanent teeth to break through. The imagines about wisdom teeth and the attitude is the final stage of ode unto genesis. Looking at all, even lucian humans have no need to adjust that sets of teeth. But with People Living to an increasingly higher age, odd to me to last longer too. And on dietary habits caused them to fall out prematurely tooth decay, for example, is one of the most Common Health problems in the world today. So if that set of teeth would make a lot of sense for searches around the globe have spent years on the development of regenerative chief at violins, technical university, scientists managed to produce funds that couldnt ferry springs new teeth. So that means i know well have to make do with all schools solutions. The people with alzheimers disease become increasingly forgetful and experience problems with orientation and speaking to most patients and their families. The conditions progression is a painful and distressing ordeal. Many patients require support with otherwise routine tasks out time is the most common form of dementia and remains and incurable brain disorder, the medication available to date, to know me alleviate the symptoms, but not put in into the new compounds all. However, in development, in may 2023, an American PharmaceuticalsCompany Published a provisional findings from a study on as outside the onto body to none of them up the 47 percent of patients treated with a new compound remain stable on 40 percent. So lets decline in their ability to carry out today the tasks the coordinates. So there wasnt improvement in cognition. And thats one of the crucial differences should be anti bodies used in the past. And before going to have access to the Drug Research a 100. So it was, they didnt move out of hand in the development of a similar auntie party therapy many years ago. But compounds deployed to data had only a limited effect, the windows sheets for those who do not know the difference is that the minimum oper moves in a central super toxic peptide. Upload them dyspeptic a course source of crystallization and platform age between 76 and a 107. At that time up to one conspicuous finding was that the intellectual faculties had evidently not been compromised. Despite the out some of clarks. Ready even nuns with a large number of products and that brains were still able to perform mentally challenging tasks right up until that processing didnt understood in whos on the we were fascinated by the non study back then all of this was prompted a lot of scientists to ask themselves with the blacks where the central element in the triggering of the disease. Ringback in the us losing or whether it was parts of the plaques that were playing a decisive role. The the views and just wanted to be drugs developed to date things to support patients memory capacity. But the results were of limited effect until the development of an antibody treatment tucked in particular components of the plots might to knock them off. Now, mean a breakthrough into teen pont is scientific direct to other german outside of the research association, cheese, web, premature celebrations, changing the cost of the patient has done that amount, but its still not a game changer. A cons actually stone to disease or symptoms. Ill give them a tool in the shop and come is a kind of best delay the progression of the disease. But whether this will be tangible to patients is questionable in the dark, the even that would be cause the hope for a lot of patients and their loved ones. Even given the side effects in the brain swimming was detected in 24 percent of cases. And the c one to send in both micro hemorrhaging point and the vast majority of cases, the side effects what a symptomatic. But 1. 6 percent of cases involved severe side effects. And that way even 3 depths related to side effects. Phillips of one from even, even though its hard to say what the new anti party will lead to a q a. Some research as belief, just as the disease itself progresses very gradually, the new antibody might need quite some time for its healing effect to fully develop. So use of Clinical Trials will be required before a Fair Assessment can be made. That for from this edition of tomorrow today dw science showed thanks for watching and see you next time the the, the, the shift your guide to life and the digital flow of the latest online trend. Navigate your way through the digital jungle global perspective. Well be, youll guide and show you whats possible. You decide what really message to you shift in 15 minutes on the w new or whether youre seeing new hi, my name is something that you meet. The gentleman tells us about the differences. Surprising similarities between germany under the home country india, in why the euro 9 in 30 minutes on the, the german or emphasizing the Award Winning offer is available worldwide. Every language level. Reading gentleman has told me to go with evelyn charmaya. Welcome to my pod cast, loved the matter by celebrities influenza and experts to talk about all plain loves. And yet today, nothing less the south. All these things in more and the new season of the fuck. Com. Make sure to tune in wherever you get your thoughts costs enjoying the conversation because you know its last matter the engine beer, you belong to the 77 percent because i just got in 65 last last those top 5 years. 3 reasons why one wants to use to help you make up your mind all the topics. Im much up to you from trouble topics, the new culture financial team. And lets say whats the quote the, this is the w news slide from bartlett, the u. N. Says its sending emission to visit new garner car box. It comes after a mass exodus of Ethnic Armenians from the region this week. Also coming up new york under water, the big apple is facing slash floods that have disrupted the cities some way the