And a very well welcome to the business. I want to get johns in the language to have you with us, starting with what could be a major shift in global trade this weekend. And at the latest, representing nearly a 3rd of the worlds population will launch the regional comprehensive economic partnership. The new free trade zone will be bigger than the European Union and the us mexico canada area combined. This is one summit where security can afford to be relaxed despite appearances, and on our guard, a smattering of dignitaries and even a choir. This biannual meeting of Southeast Asian nations will, for the most part, be an online affair. Another casualty of corporate 19, vietnamese Prime Minister hosting the meeting laid bare the challenges the pact faces. We are going through an extremely difficult time as corporate 19 threatens the lives and livelihoods of our people. Economies and societies are in disarray. He further washed in by severe natural disasters from drugs flooding to continuous storms. Leaders will also discuss the troubled waters of the south china sea. For years, beijing has been pressing its claim to virtually all of the seas, key, fisheries, and waterways, creating friction with our asean members. In the bilateral meeting, there was little of those tensions on display were continuing to recreate the chance to address the differences and disputes our countries. They only have to recognize that such problems. Im not the whole picture for a china aslam rim ation chip. And this is why the regional comprehensive economic partnership, after 8 years of talks 15 nations including china, japan and australia are set to sign the Worlds Largest trade deal. Its members account for almost one 3rd of the global economy. One trade minister said it was the culmination of blood, sweat, and tears. Part with the regional rivalries, though, simmering, and a changing of the guard in the usa. There may be yet more unrest ahead well and matthew moore, who did this report is here with me in the studio, matthew, the Worlds Largest, the biggest free trade zone in the making. And that region needs some good news, doesnt. It doesnt mean this is what one analyst said is a hugely significant moment for trade and investment liberalization in the area. And lets remember the backdrop to this is the catastrophic collapse of qana means that occurred with the coronavirus pandemic. And thats why the meeting that virtually because of the, you saw g. D. P. Can create a across lots of countries. And this is about a glimmer of hope. Its about trying to kind of re, we cover some of that last the last trade. You saw the g. Ds p. S. A. Was it was 5 percent. The site is the asia was the, was the Fastest Growing region, one of the farcical regions in the last consul. This is about trying to recover that. And theyre hoping that we just get to, as im going again, encourage investment that it will boost trade. But of course, those that, that trade didnt come about overnight and certainly not. Now during this pandemic, those talks were going on for years and years before that. So there was a big interest there, but whos actually in it now and who isnt . Well, weve got the 10 in countries with china, japan, australia, south korea, new zealand. Are the big one is in there for a while. Theres a couple, theres the 1st of it is india and it was a post again, until november last year. So a year ago they were in there and then they pulled out because they were unhappy. Business leaders in china and india said that this is going to swamp our market with cheap chinese goods. I think theres a sense in new delhi that they werent going to get the kind of concessions that they think a trade deal merits from the chinese in terms of the service sector. So they pulled out, they still have the option to rejoin at some point in the and obviously the other big player, global player, thats not there is the u. S. And thats because this is kind of seen as chinas deal. The reason were talking about this deal today and not the transpacific partnership, which was the u. S. Deal. And that got dumped on donald trumps. For example, the 1st, its not u. S. Steel anymore. As you bring the 2 big player, is it in the here china and the u. S. I mean, how is this deal now impacting the that sort of power game that we see . Think china is, is, is, is no ones the sign thats on sunday, as to is the youre expected to do. China becomes the kind of dominance. That cements itself is the big player in the region. There has been the kind of sense that the u. S. Has an appetite to try to resuscitate the trade deal that they spent years working on. But they might still prove they were. I think they will still exist. Some, some pressure on china, on the south china sea, the shipping channel is really important for local economies, but also global trade. And they dont want to let china just just carry on with, with theyre trying to cut take over other territories. And again, and well simply dominate the region and they dont, theyre obviously in the water and specially now with, with this deal, which will probably be signed this weekend. Matthew moore, thank you so much. Well, matthew mentioned the coronavirus epidemic. And spain, of course, is among the European Countries hardest hit by it. Its death toll just past 40000. 00, the ongoing lockdown as weighing on the economy, especially hotels and restaurants. In sayville, thousands are taking to the streets to vent their anger. Their sign says without aid will be ruined. Thousands of workers from the hospitality sector are on the streets, demonstrating theyre protesting the dress to coronavirus measures introduced by the government in and a lucio. Since tuesday, all restaurants and bars have had to close at 6 pm. The curfew starts 4 hours later, i think the government and the situation is absolutely deplorable. Everything thats happening is unbelievable. There are sectors that are more contagious than the parson, demonized. And so no one is helping. Theyre letting us die without providing a solution. In other regions of spain, like catalonia in the northeast bars and restaurants have to shut down completely for 10 days, perhaps even longer. Everyone here is afraid that the new situation will set a precedent in spain, 17, regional governments decide autonomously on pandemic measures. The protesters are demanding the Central Government in madrid and the confusion and help all those affected by knocking off. We are not receiving any direct aid, and politicians need to stop passing the buck. All the government has a responsibility to help put together a National Financial bailout of our sector. The government in madrid says its working on a solution, but the people here say its anybodys guess what that might look like. And its not just the spanish tourism 6, feeling the pinch as a delay and he now joins me in frankfurt itself. See the to agree, the worlds leading till recent group actually said it may have to sell hotels and other assets to stay afloat. That sounds very dramatic. It is very dramatic for tyria. Theyre fighting themselves once again. Quite close to the brink too. He has already gotten 2 bailouts from the german government, but theyre now saying that that money is not enough and because theyre facing so many effects from the pandemic, including of course, these huge slowdown in travel, theyre having to refund a lot of travel that was already booked, they have quickly run through a lot of that money analyst at citi group estimate that the only have a couple 100000000. 00 euros by the end of the year. So they need to really see where they can cut theyre looking at asking for more aid from the german government, but theyre also looking at selling other parts of their business, potentially, hotels, planes, things like that. All right, when downsizing is one thing by looks like a bottomless pits. I mean, what could save the industry . Obviously theres a lot of hope and on the potential for a vaccine. We did see a lot of these travel stocks including shoot up earlier this year after pfizer and biotech release. The positive results of their vaccine trial. But at the same time, there are still many outstanding questions about how this will impact travel in the long term. A lot of c. E. O. s are still something quite optimistic about the return of travel once a vaccine is found. But will say were going to have to see exactly how people respond to the reopening of travel d. To chelsea, delaney, and from food. Thank you so much. Well then, another side of the pundits, of course, people Shopping Habits changed the cosmetics industry in front. So many sales around 40000000000. 00 worth of products every year, but who needs expensive makeup and a face mask instead of soap is selling like hotcakes. Its a truth that no amount of cosmetics can cover up. Customers and friends have been changing their purchasing habits since the coronavirus pandemic. I dont care. I hardly ever put on makeup nowadays, just a little mascara on someones derisory. I really dont wear it anymore with the mask. It doesnt make sense to me that ive changed my make up style less lipstick, although i really enjoy it. More skincare your mikey will, whom i use a lot less no lipstick. Its not just a cultural loss for france, but also an economic one. Cosmetics are about luxury, its one of frances leading industries in terms of sales. The only Silver Lining is that the sector also produces products that are in higher demand during the pandemic. He will receive through the book. Really, one of the laws are very hard. Hygiene articles such as soap and shampoo, lose before have seen strong growth because they play an Important Role in fighting the pandemic. But normal makeup sales have suffered. If you get more powerful to more the virus as trend setter, its better up the development of an industry wide trend that has been in the works for years. Less make up more wellness products and sachets in jars all designed to pamper. Weve seen the trend coming, but lock down, made it stronger, and its still going strong. We sell organic products. Natural. Do it yourself. Around with there, if you do it, youll say level mighty high please. The cosmetics sector has always survived by feeling the pulse of the times, and its doing that again, practical tips for picking the right color. Well, make sure it matches your mask and is your Business Update here at the w for me of the team, as always, thanks for keeping us company. The phone against the corona virus pandemic has the rate of infection been developing. What does the latest research say . Information and context, the coronavirus update on t. W. How does a virus spread . Why do we panic . And when will introduce through the cover and the weekly radio show is called spectrum. If you like and information on the coronavirus or any other science topic, you should really check out our podcast. You feed it wherever you get your podcast. You can also find us at dot com slash science. Over 30000000, people have contracted, covert and recovered. Then up to leave, to have natural unity that typically offers better protection than a vaccine, but the price is higher with so many unknown long term effects. Vaccines may not be quite as effective, but theyre also not as dangerous. Not only not influenza. And i was very well one, even in some compare it to a hangover human trials of several vaccines now to positive results. But that doesnt mean life will go back to normal just yet. Here in an old peoples home in italy, the vulnerable can once again get close to their loved ones, but in a different way. Were making progress. The Serum Institute of india, the Worlds Largest vaccine producer, says its made 14000000 doses of astra zeneca, potential corona vaccine. Its a bold, 600 participants for late stage trials, and soon it will be making novaks rival shorters both seek regulatory approval. Indias vaccine is big service has always been important enough from donating blood since a young age to Holding Treatment drapes. He was disappointed when he couldnt join the indian army to serve the country, but then another opportunity and hes not in the infant. Only group that came along. He volunteered for the Clinical Trials of a covert vaccine being developed in india. People told me it was risky for me, it was an opportunity to be of service. Im happy to dedicate my body to my country, my fellow country men, whenever im needed, ill be there. It was this enthusiasm to want until for the covert vaccine trials that stood out for dr. Savage that bad mom in previous Clinical Trials talked about not has led much more convincing to find volunteers for this one. She had hundreds calling in within days. So many people came forward because they wanted to do a greater good. And a coffee is one only within 34 days we had to have people and that is stirred with us. Im just isnt just individuals in india who are trying to plead their part to help deal with this. Pandemic 1400 kilometers away. The western city of 20 is home to the Worlds Largest vaccine to do so. The 7th student and get produces over 1500000000. 00 vaccine dollars every meal for use in one second to countries. Now it is poised to play a crucial role in the global bid for the put on of my dyslexia. Already, this facility is producing 30000000. 00. This is all fuel for a vaccine every month. It just set the stuff i in 300000000. 00, this is by the end of the you. We rejigged out capacities. We sacrificed a lot of products that we were going to launch in europe us, and thats why we were able to have that much Spare Capacity available for making these 45. 00 different covert vaccines and only at the low cost of a few 100. 00 rupees. Duffy 45 year olds with the help of the gates foundation. The institute is investing to provide vaccines to over 91000000 combine trees at an affordable cost for other vaccines at different stages of trials are also being produced. None of these have been approved yet, but the companys c. E. O. Or other novella is confident that stopping production already with the support of the Indian Government is the day if and when the vaccine is licensed, we have a lot of product that we can distribute. Of course, its a risk of the product for whatever reason fails of the last minute, which now let me say looks very unlikely. Now things are looking far better, please. For the Oxford Astra Zeneca vaccine, we have all expects emergency approvals for the oxford vaccine to come through early next year back and brought back meat with tb coming in full for the tests next year. That check how well he is doing with the back. And he will not be alone. While his father was at 1st, voted for the safety of his son. He has now been swayed by love, needs into the, as it were, and well out of the city who is now a vaccine trial volunteer as well. And proud to stand shoulder to shoulder with his son in what he sees as a service to the country and to the world. While scientists continue to work on a coronavirus vaccine, lets talk to life alexandr about vaccines versus Natural Immunity. So whats better getting infected . Recovering and becoming immune or an actual vaccine when it comes to covered. Well, at this point, its hard to tell because we dont actually understand exactly how long lasting, how long lived Natural Immunity is after the 2 infection. So far, the data indicate that antibody responses are quite durable, at least over the course of 5 to 6 months. But we dont, dont know how long that will last. What we do know is that from, and any coronaviruses other coronaviruses that cause the common cold, that the immunity is not that long, that you can get reinfected after one or 2 years. And the hope is that with the vaccine and used immunity, that they will be able to produce a more long and more robust immunity than natural infection does. Because for some other diseases, the vaccine actually does enjoy a better immune response than the natural infection. And then vice versa with others like measles. Exactly. So there are examples from both. There are some examples where our natural infection induces a much more robust and long lived immunity. Then vaccines have been able to do. And other examples of vaccines are better than the natural infection. And then often as do with the pathogen or the virus that causes the infection is that virus has the capability to escape the immune system. As in the case of h o, b, or certain herpesviruses, the viruses are able to hide from the immune system. And the hope is that you can create a vaccine that is able to bypass this property of the, of the virus to ha and, and this plate and use a more robust and more long lived in unity. There is also, there are many unknowns as far as the long term effects of covert go. I mean for young and old blood clots, heart damage, Chronic Fatigue, memory loss, fertility issues, seizures, temporary paralysis, increased risk of poc and since outside is there any added any others . That youd like to add to the list . No, definitely. There will be long term consequences of covert 19. At this point, it is still too early to tell how frequent they will be and how long these. And these consequences and long term effects will be what we do see is that theres quite a substantial proportion of people that suffer from fatigue and Chronic Fatigue syndrome. That is a very severe condition that basically descent leaves, patients unable to work unable to go about their normal lives for several months. Then there is other effects such as off the respiratory system. You see people severely compromised for several months after the infection. And of course, we have these neurological effects that you mentioned. So in addition to the quite high mortality and the strain on the healthcare system, we have to take into account those long term effects. And that makes it more important even to have as effective vaccine and what do you expect an effective vaccine against kobe to be able to do so the studies that are currently being carried out, and also the 1st study where interim results have been reported. Have been designed in power to show every direction probably to infection symptomatic infection. What i would hope, which is a secondary endpoint of many of the studies, but i would hope, and i also think that they will be able to do is to reduce the frequency offs of the equipment, which means reduce the frequency of failure. The people have to be into it and treated in the i. C. U. And also to reduce mortality from berlins shot at a hospital life effects on the thank you very much. Finally, your questions is our science correspondent, Derrick Williams by amtrak and pfizer have developed a vaccine to provide covert 19 are there pharmaceutical companies also working on therapies to cure patients who already have it . As well celebrate very promising interim vaccine candidate results and look forward to possible breakthroughs with others soon. Its kind of easy to ignore the elephant in the room, which is that covert 19 is going to make this winter in the Northern Hemisphere of long, hard and likely very grim, even in a Perfect World with a vaccine approved by the end of november. It will take many more months if not years to distribute it. And although doctors have gotten better at treating patients, thereby improving survival rates, we still dont have really effective drugs to treat those who become ill or who become very ill. In fact, a major disputed preprint Study Released by the w. H. O. Last month. More or less said that most of whats in our medicine cabinet now, that can be produced at a large scale, basically doesnt really work. So why dont we have more compounds to help people who have the disease and are in dire straits . Well, for a couple of reasons. In some ways, developing tailored treatments is a trickier process than developing a vaccine. Because vaccines all do the same thing, they stimulate the immune system to fight off an invader, so we can judge end points pretty clearly. Can it do that safely and can it do it effectively . But treatments usually have incremental effects and can affect the disease process in a lot of different ways, which is why in the search for therapy, we focused on what are called repurposed drugs, treatments that we already have that work for other diseases. And most importantly, that have already proven safe to take because it all had to go fast, right . So, so yes, thousands of drugs have been screened or are in repurchasing studies and some are promising. But as, as we approach a year of covert 19, we still dont have therapies that can knock it out effectively. To the point of strong opinions, clear physicians, international perspectives. The dust has not really settled on americas president ial election. The one thing seems certain if and when joe biden enters the white house, hes going to adopt a very new and very different foreign policy. Find out more months of the point, short is to point us to the people on d w. What keeps us in shape . What makes us see and how do we stand . My name is dr. Carson because i talk really connects them, watch them at work. And i discuss what you can do to improve your health state use and lets all try to stay safe and good on w. The power of words where i come from and i never saw the sun when it took to heaven on earth. In brazil, the sun was always the man since the boy took his word for sun, its masculine. When i moved to germany as a 10 year old, i was 2nd to none t. V. And that would change how i see the world. Because in german, the sun was feminine seeming now but the side of a good listener. So i was upon the tape instead of a deep voice exterminate the guy seemed absolutely incredible. I realized how language shapes the thinking, how definitions are not only a mental image, just put our whole perception of the world is inside, save my life and was one of the reasons i became a journalist. Im a storyteller, and i use my words to help with intercultural understanding. My name is the one where you and i work and to doug. This is from the u. N. Says the situation in ethiopia could be spiraling out of control. The conflict in the countrys Northern Region intensifies saying a number of civilians also smarts the 5th anniversary of one of the worst terrorist atrocities in its history. Islamist militants killed 130 people