Beethoven is for. Beethoven is for. Beethoven is for everyone. Beethoven 2020. 5th anniversary here. Is covered 9000. 00 cases spike in some countries its clear that the pandemic isnt slowing down thats why many of pinning their hopes on a vaccine. Were pretty cautiously optimistic that at the end of the year beginning of this coming 2021 we will have one in maybe more. More than one vaccine that would be available. Thousands of scientists are now working on more than 150 vaccines but none is approved for use so just how close are we to getting an effective coronavirus vaccine. Past the big question welcome to your coverage 19 special into w. News i want to jones and berlin good to have you with us the fight against the pandemic is gaining momentum the u. S. Food and Drug Administration has granted Fast Track Designation to get 9000 vaccine candidates under development by pfizer and its german partner biotech now this is an important step towards getting approval for a vaccine in the world is desperately waiting for. Things are moving quickly at biotech the companys search for a vaccine began in january by april it had already begun Clinical Trials research at record speed. Production has also been racing ahead. The European Investment bank has pledged a 100000000 euro loan if the human trials are successful. Buying on tech and Pharma Companies all over europe are gearing up for mass production of a potential vaccine even if success remains uncertain. You are already equipping our facilities and finding Production Partners all over the world to help us produce large quantities as soon as our production process is up and running will also start producing on stocking it despite the economic risk of having to throw away all this vaccine if it doesnt succeed in trials. So to me. An impressive number of projects including sars kovi 2 vaccine trials are underway at universities and companies in germany switzerland and austria but research is advancing all over the world 23. 00 substances are already being tested on humans in projects mainly centered in europe the u. S. And china all told scientists are now investigating more than 150 different vaccine candidates nerdish this is necessary because its quite clear that no single manufacturer could really meet the worlds vaccine needs Global Demand can only be met if several companies are producing in parallel each with their own facilities and with their partners. So on for. Buying on tech says it could have a vaccine as early as december of a more im joined by professor klaus see what take president of the institute thats the German Federal insist you for vaccines and biomedicine its good to have you with us so we just heard here at the end of the report a vaccine by december of this year how optimistic are you that this will work out. I think generally im very optimistic that well have fiction products the truth will be fired from marketing or 3 stations in the u. S. And europe in general for example the Company Value on take has provided us with a kerching immunogenicity day 2 and a couple of those switches they use for face one to trial and also all the tolerability of the store switches which is very important they have also found out that one of the large doses its not so well tolerated but i think the next step will be to start low fish 3 ficus e trials and also get take some more information on the vaccine safety in brazil us and germany then there is a very good possibility if the state a call positive such filing excuse for marketing or 3 situation could occur we. The European Medicines Agency have already indicated that a rolling review would be possible which means that once the data come in they can be submitted for review by the regulators one of the of the right of course when we talk about thousands of scientists currently working on developing a vaccine against 2 we also talk about a huge variety of approaches by intake is working on a socalled Nuclear Assets vaccine thats based on genetic instructions lets just take a quick look at how this works. To develop an m r n a vaccine scientists have to access our c. O. V. Tuesday night a code they can then synthesize messenger r. N. A. Molecules that carry information from the virus like how to build specific proteins the synthetic m. R. N. A. Is enclosed in a liquid nanoparticle which delivers the vaccine to ourselves once and signed cellular machinery follows the m r n instructions and begins producing the viral protein which is then displayed on the surface of the cell that stimulates a protective response from the immune system. Not professor klaus thats here take from the pal and institute please tell me what makes an m. R. I. On a vaccine a good candidate in the fight against. Well 1st of all we have to say that the regulators are open to any kind of acts of platforms that are currently developed skin to take actions against corporate 19 what makes our navy actions attractive is the Technological Progress that has been made to in the last years and although we dont have a license human to prevent infection yet we know from studies at least in the preclear the calorically nickel trial phase also on chuma vaccines that they are generally immune luton that jenny the next point of course is that they use Genetic Information and so the steps that are used to be used for Vaccine Development which are isolating the virus getting that Genetic Information decking the virus the cell culture and bringing it up in the high cell culture can we are made it within our night vixen so we are left with a lower bio safety limit and the other plus is of course that companies have announced that they can produce millions and millions of excellent doses up to the formulation with and 6 weeks or so thats what even if you know thats what we need of course but people also have to be willing to be vaccinated and as you know there is a lot of resistance and to anything that is genetically modified from crops to drugs how justified are these concerns especially when it comes to m r n a vaccines. Well 1st of all i dont think these prejudices still exist when it comes to the application of Genetic Information and Gene Technology in human scent in medicine because it has been shown that this is a very effective and very safe to culver city number 2 with our navy since we dont have the issue of and even cooperation of secrets is into the genome of cells or be it the germ line nothing like said cant have because our name is rather fragile molecule and 3rd of all with all the different vaccines no metal with it we know the platforms already in detail and not there always treated as one unique new thing that we need all the data about truly understand their safety and fick you see so the end is that the regulators have to come on the basis of data to a benefit risk evaluation that has to be right at the preventive vaccines we really need a large plus to the benefits compared to any risk that we may take into account so its safety 1st thats good to now professor to take from germany is that the institute for vaccines and by medicines thank you so much for your time it was a pleasure thank you. Well next up this is Derek Williams says he of course is our science correspondent and he spend the hard work on seeing your questions about 19 is our latest installment. Does a rendez of your work against covered 19 and how. Does appear is an antiviral medication that was originally developed to fight ebola that has been repurposed in the fight against covert 19 which is why its come so far so fast in trials usually that whole process takes much much longer in the meantime because it proved safe during testing in the last bowl the epidemic thats been approved for emergency use in many countries for covert 19 as the pandemic continues to rage supplies of rendez of year worldwide are running short even though a final Regulatory Approval in most countries hasnt come get the drug works by interfering with viral replication inside the cell it kind of throws this this Monkey Wrench into the into the viral reproduction process studies have shown that it can shorten hospital stays for severely ill coded 19 patients the company that produces the drug nelson is that its Observational Data shows that run does appear also reduces mortality but that still hasnt been confirmed by by Clinical Trials. Is covered 19 latent like herpes. The number of viruses not not just the ones that cause herpes can go dormant in the body and then then reactivate at a later point in life chicken pox for exam. Or does it even if you had chicken pox as a child the virus that causes it can remain dormant in your nerve cells and manifest even decades later as a skin condition called called shingles so so after an initial infection could soras cove to also go into hiding in your body although its true that many patients struggle for months with symptoms of a pope in 1000 infection that isnt real dormancy and the way we usually mean it is generally the viruses that are able to lay low in the body for decades are our d. N. A. Viruses like those that cause chicken pox or herpes or theyre already retro viruses like the one that causes hiv and coronaviruses dont fall into either one of those categories so although nothing has been ruled out completely weve never observed latency in corona viruses and we dont expect it from source code to. And Eric Williams will be back again tomorrow so if you have what questions to just post them to derek on our you tube channel if youd like to keep up with the latest developments on the corona virus and to subscribe to a newsletter just log on to d w dot com slash corona dash. And that wraps up this edition of 19 special for me in the c. N. N. Berlin thanks for watching stay healthy. This may be season. But nobody ever dreamt of the way it did. Still some things never seem to change. Plus one of our. Own w. Passion drama competition rivals marketing numbers on those here probably by that time and traditionally paid money. The fans are in the fire. Because women love football. Cuts. To go off on you tube joining us. Now live from show that of us are. In support of. Saving whats able. To bring about. 2 these quite as simple as it seems. To understand the world better we need to take a closer. Experience knowledge. Borrow to do it. On the job of. The barstow saragosa not going to the. 201920 buddhas legal coronavirus crises notwithstanding its been another fast and