Humans our eyes if all goes according to plan. With modern technology taking a look at the retina on the back wall of an eye is easy and routine but actually going in there to treat disease is much harder i drops arent enough to tackle serious issues. Corkscrew shaped nano robots might be the solution theyre 200. 00 times smaller than the diameter of a human hair this is a computer animation. The idea is to send such nano propellers through the vitreous humor of the eye to deliver medicine to the retina professor pear fisher at the Max Planck Institute for Intelligent Systems in stuttgart is among the scientists who are developing these nano robots. But it becomes not in developing the nano propeller we found inspiration in bacteria we recreate. The screw like structure that enables bacteria to move because when you rotate a corkscrew it moves forward fall thats what makes. The nano propellers are made by the big prize in silicon dioxide and other materials including iron onto a copper or silicon wafer under high vacuum while it rotates. The way for is already coated with tiny polymer particles. And each one a hey look old nano propeller is born out of the vapor. This way for is covered in billions of these nano propellers. You need a microscope to see them. They are very small and they fit to the mesh of the vitreous they are only 500 out of me they are in the average there until my call so they can easily sneak through the mesh of the vitreous. The propellers have to be harvested from the way for. Bits of the way for are broken off and put into water. In ultrasonic bath disperses the particles. Each truck contains a large number of them. For a nano propeller to move through a body without getting stuck it has to be both tiny and slippery. So the team developed an anti stick coating. The chemical for the coating is called fluorocarbon so its a long chain carbon that doesnt want to stick to anything so its a light. Similar to the coating of your test for cooking. At tubing in university i hospital nano propellers have been tested in the eyeballs of dead pigs and shown to work. The nano robots are magnetic so they can be steered by electromagnets outside the ai. Their movement can be observed in real time with the help of an imaging technique known as optical coherence tomography. We just we could just monitor live how the particles move through the eye and we were able to steer them to the exact spot they were meant to go in order to establish that the nano propeller had really reached the retina the pigs eyes were frozen and then cut into thin slices. The microscope revealed that the propellers shown here in red had indeed arrived at the retina here lou. Before such nano Drug Delivery vehicles can be used in clinical practice several problems need to be solved. How can they be removed from the eye again. And how can they be made to carry and release a cargo of medicine. Or may not have to load a nano profile or we can make use of the chemical actor buttes of its surface to attach certain molecules by means of a chemical process we can also make the helical body porous and theyve going molecules to be transported within the body. If and when all the obstacles are overcome this new technology could revolutionize the treatment of diseases of the retina but not only the retina. Many parts of the human body are hard to access in a minimally invasive. Are. Tiny slippery steerable submarines likely use might be able to reach parts other methods can. Suddenly means explore the deepest reaches of the oceans and the bizarre life forms that thrive there. But theyre all mysterious rounds to be explored much closer to home. One prime candidates is our guts our gastrointestinal tract all 9 meters of it its teeming with wildlife we cant do without. Them so lets go exploring. Introducing louisa. The german name for the common european pair grown by the shores of lake constance. Its about to go on a journey through the human digestive system. To. Alex a pretty rough ride from the get go our teeth take care of the basic mechanical side of breaking down the fridge next the ground up food costs to be a softer guess on into the stomach. The reason the pair then spends an hour or 2 drenched in the massive box in preparation for the next stage and that takes place in the small intestine. For an insiders view scientists at this german Medical Research Center have a cutting edge small oval camera at their disposal but for all the gotcha tree precious little is known about the inner workings of our intestines. Foliage the micro biome is largely still an unknown entity within our body even more so than much of the surface of the moon its something weve only been able to start examining very recently in that respect its like a black hole shots is. The 1st part of the small intestine has no microorganisms and is remarkably smooth louisas trekked through this part of our body takes about 3 to 7 hours. The surface area for digestion is greatly increased by countless little projections called villa this is where the body extracts most of the nutrients which are broken down with the help of enzymes but as the parent tells deeper it encounters more and more microorganisms. Is home to over a 1000 different species of viruses fun guy and bacteria which make up over 90 percent of our intestinal flora as well as helping us on the digestive front they also play a vital role for our immune system they even provide us with nourishment from the products of their metabolism in the form of vigilance for example. Moving around stimulates our digestion what remains of the pair has not reached the large intestine or colon where it will now spend the longest period of its journey between 25 and 30 hours. Once in the cold reserve the pair is set upon by legions of microorganisms extracting everything the body has not yet been able to digest. Their prime target is louisas dietary fiber on the polysaccharides it contains. Once broken down they use short chain fatty acids beauty rate for example is used by cells in the gut lining as an Energy Source this is why a healthy diet includes plenty of fiber from vegetables. Major shift in the balance of bacteria can lead to dangerous complications. Because i know. We know for sure that when particular bacteria are killed by prescribing antibiotics other bacteria overrun the gut flora. That can lead to a serious inflammation of the colon which is called pseudo membrane the. Good bacteria are more or less wiped out there are harmful bacteria that are resistant to antibiotics and can now multiply unchecked such as close to. These pathogenic bacteria produce a toxin that attacks the god lining and compromises its ability to protect our body from infections. For the end of its journey the pair has been almost completely decomposed but our body ends up excrete dead intestinal cells and bacteria practically no residual food. And in the case of louise of the pair its the fiber that makes the journey so worthwhile for the benefit of our micro biome. Several kinds of fruit give us plenty of that good diet because of the pectin found and then. Some kinds of pectin might even help. So benign as for example are a great food for many people. Here in the us sense in an interesting question about how bananas reparative. Bananas grew from seats. Wild bananas to have seeds stonie blank seeds that can germinate. Normally with flowering plants pollen from one flower is carried to another where it travels to the ovary and fertilize egg cells to make seeds. The seeds containing the Genetic Information to produce a new plant the commercial bananas we buy in supermarkets dont contain any seeds theyre specially bred to be seedless to make them tasty or. These bananas are in fact the result of a genetic accident that gave their cells 3 copies of each chromosome instead of the usual 2. That made them seedless much tastier but also. The most common banana is the cavendish theyre all genetically identical each one is a clone of the other. New banana plants are bred from off shoots of a mother plant. d worldwide most bananas are bred by taking cuttings and growing new trees. The advantage of this cloning system is that all bananas have the same thick skin at the same speed and can be transported at the same time. The disadvantage is that this genetically fragile fruit is vulnerable to diseases the fungal disease tropical race for is currently ravaging the global banana industry from asia to black in america. Researchers are currently looking to save the worlds most popular fruit from extinction by crossbreeding the cavendish banana and the more robust wild banana. Sweet things have a huge fan base among as humans. We are programmed to crave them. As a quick source of energy for our body something our stone age ancestors should evaluate. Now adays we dont need as much energy to hunt and forage for us. But that doesnt stop us from craving sweets stop them from any number of sauces. Cakes and candy is it a sweet and should get us. Thats the mission of researches here at brain biotech in central gemini theyre looking for a sweetener thats not artificial. And theres one crucial qualification for that natural ingredients. Is will not do we want to find a sweetener that tastes just like sugar or enhances sugar to a degree where you need less of it but with an identical tickets to the old products its. A requirement that mostly is today to fail to meet which is why and lot of people arent keen on them. And research is a still not sure about how exactly artificial sweeteners work in the body d aspartame has been comprehensively tested and widely approved but critics say its linked to a range of side effects such as headaches and impaired vision. Researches have also discovered that unlike sugar sweeteners do not release the time at sea hormones so people who consume them feel less full they also fail to activate the reward center in the brain the results could be eating more and even gaining more weight despite sweetness having next to them count of rings almost all sweet as approved by the e. U. Are artificial the sole exception is stevia approved by the e. U. In 2011. Its actual use is however a limited. There are products that dont work very well in conjunction with stevia hardly any Dairy Products are sweetened with it for example due to the off labors being too pronounced were looking for a superior sweetener superior version of stevia as opposed to. A super version that also meets taste expectations and that involves breaking down the Building Blocks of nature these researches have a deep freeze. Story of cells and natural substances from countless films and funky and to so far analyzed 20000 samples the vital substances can be hidden away in edible or inedible components in tiny molecular compounds that contain mia traces of that all important sweetness among todays test subjects is red meat one single plant can contain hundreds if not thousands of compounds which all need to be tested in a complex and costly process. But they have help in the shape of an artificial tongue. The same size heads this is the most vital element in our research these artificial cells enable us to quickly test the properties of thousands of substances and how sweet or bitter they are each of these tiny vials contains taste cells extracted from the human tongue they react to the samples tested once the cells receive a sweet signal they release messages that in turn become visible the plethora of light signals show that the red meat has plenty of potential. Was it takes a real human being to tell the difference the researches have subjects compare 2 samples number 2 is the natural variety taken from the bread built. The 1st sample tasted sweeter the 2nd had a slightly metallic after to distinguish. Which doesnt bode well for the red meat samples that fail at this stage or of no interest to the research is. Another candidate gets top marks and the taste from a sweet protein from the pen to deploy. Their fruit native to Central Africa that taste is not the only factor the suitability of substances varies depending on the product. To stop it is there are sweeteners that are great for drinks because they dissolve so well whereas some sweeteners have an excellent test but arent so soluble theyre better suited for candy bars or chewing and thats about. It and while taste is important so with the short and long term effects of sweetness. It will take some time until a sweetener is found that his most effective old products and of course natural. Not always bad for us it depends on what kind and how much. Polysaccharides found in complex carbohydrates and grains for example dont cause blood glucose levels to spike theyre also considered beneficial dietary 5. Simple carbs which break down fast into sugar are found in candy they usually dont make you feel full and do make blood glucose levels which is bad contribution to obesity and disease losing weight can be difficult and hard work can science help us to cut corners. Imagine a safe and effective pill that will really make your fact go away thats what t. Mo miller and his colleagues are working on and they say theyre getting close. To home and it came as a surprise but we were delighted for it. The breakthrough involves using 2 substances one that burns fat and one that suppresses the appetite to create an effective combination therapy. There have been countless attempts to find ways to help people lose weight many pills are touted as the real thing. Online you can buy any number of products that claim to do wonders without you having to do more exercise or eat less most of these claims have been shown to be bogus some products are downright dangerous. The researchers at the home holds Diabetes Center in munich aim to harness a certain capability of the human body but it was only discovered a few years ago brown adipose tissue or brown fat doesnt store energy but uses energy to generate heat quite unlike regular white fat. There are deposits under the collar bone in the neck and along the spine cold temperatures stimulate brown fat we only have a few grams of it but it plays an Important Role in maintaining body temperature and burning fat the idea was to develop a substance that mimics cold in activating our Energy Metabolism. When participants in an experiment spend hours in a room left at 16 degrees celsius the volume of that brown fat grows in the same effect to be generated without the chill factor t. Mo miller says the way to do it is to deploy a substance called isolate. Is an agent that activates signaling mechanisms in the brain which in turn activated brown fat fit. The upshot is that the Energy Metabolism speeds up and bodyweight declines. In tests with mice it works but the amount of weight loss is modest so Something Else is needed another component to the fat. There are so many nonprescription weight loss pills are and many are entirely useless some are worse than useless. Theyre harmful even if they claim to be all natural. Works of the German Institute of Human Nutrition in pottstown. Of times there are various substances that bind fat in food but the effects are variable and mostly minimal it seemed almost always come with side effects when large amounts of dietary fat dont get absorbed into the body but remain in the gut its broken down by bacteria that causes intestinal problems diarrhea or gas it can be very uncomfortable i cant recommend it. So in theory. It gets really dangerous when diet pills include banned substances that are toxic. Tremaine in particular has been associated with serious cardiovascular events thats why its not licensed for use in the European Market but products containing it can still be found and purchased on line d. M. P. Is also known to be extremely dangerous its very toxic one gram can kill you as it burns fat and carbs the metabolism speeds up and the body gets hotter and hotter. At the helm holtz Diabetes Center theyre looking for an agent with negative side effects. Isolation does indeed stimulate the Energy Metabolism and released in mice but the effect is small so what 2nd substance could compliment or boost the effect and here comes the breakthrough discovery. Of the 2nd agent is also a synthetic molecule d m p p is a small x. Very much like nicotine in that it reduces our Food Consumption but without the negative effects that nicotine has on our brain. It suppresses appetite. But not enough to be effective by itself the trick is combining iceland and d. M. P. Piece together the effect is impressive. If you prescribe the 2 together the combination therapy results in much greater weight loss than the to take it separately. And so. You could say that this is a case of one plus one equals 3. The results in mice have been excellent but theres still a lot of work to do before we humans can benefit from the breakthrough so for now the prescription in many cases but not all continues to be moved more eat less and eat healthy. The problem is right right but if they. Do you have a science question. Somebody if we answer it on the show listen give a Little Something as a thank you you can send your question as a video text or force mail come on just ask. Youll find us on our website dot com slash science or get in touch via twitter facebook. Thats all for now from tamara today next time well be diving deep into other fascinating realms see you then for more scintillating science. Innovation. Sounders valley bianco petroleum meets modern day. Cumana to be on the move in the leisure stuff founders help Migrant Workers assert their basic human rights migrants are key to the countrys growth but many legal status in this change for the next generation. Next on d w. When will this happen again. Until then d. J. Star Paul Van Dyke used phrase in new trails. Come to mind the some of the session lines stream from berlin. What made him a visit and asked what projects he can still see through. The moment. In 60 minutes solo d. W. My smiling. Face he. Painted me. I am. Just a nice move those who look at me. My and. I am an honest song from the original. The sequel. Starts july 13th dont you. Lorrie