A highly automated bus it works with our driver and it brings people everywhere because mobility is important to us but not everyone is as mobile as i am and if mobility is not there weve got a problem. Hello and welcome marc on im meeting and she suffers from multiple sclerosis so why dont you have and well check and have of will i like to go with the world at the end but ill see through a report this is what were going to talk about with professor harms hes the head of the neurology apartment here at the bridge in charity and has really gone out. And we will continue our talk in just a moment but 1st i will show you a young man who loves nothing more than to jump of high cliffs so its pretty normal life but he suffers from multiple sclerosis and hes got a you tube channel and he talks about this to his fans. But also. To be out in nature to jump off a cliff into the sea from a height of 20 or 25 meters thats a feeling of independence and freedom various kinds of fun finds. Patrick island just loves that feeling and he loves sports hes super fit though 2 years ago his body gave him a nasty surprise. I had attending feeling in my left arm and leg like ants running up and down. At the beginning flare ups were sometimes so intense i couldnt control my movements properly so i had to stop cliff diving. At least the diagnosis was multiple sclerosis patrick was 28. 00 at the time the thought that he might end up in a wheelchair was terrifying. As totally knocked me off my feet because if youve never been diagnosed with an illness like that its hard to understand how lousy you feel when they tell you its a patch that has been spared frequent flare ups but when they occur they interfere with everyday life and especially sports business or all the just monitors his condition what he does feel all the time however is the tingling in his left arm and leg. Its the result of inflammation in the brain. Multiple sclerosis is a disease of the brain and spinal cord which causes inflammation in certain areas there and that causes flare ups. These flare ups are the symptoms that the patients experience. They vary depending on the area of the brain with the inflammation occurs often. Neurological tests show that Patrick Ottman just still in pretty good shape his reflexes and coordination are barely compromised. By hand and this is the good news is that mr argent is not suffering from any serious enduring problems that manifest in everyday life and its often the case that in the early stages of m. S. Issues that arise with flare up subsided again. Still patrick does sometimes have difficult moments. I was on the boat and about to jump but i just could not what my body was telling me no not today that was a blow to my self image i fuck terrible that triggered a downward spiral of i dunno where you go on. Medication prevents or at least delays flare ups but never knowing how the disease will proceed is a considerable emotional and psychological burden. And it was if you get into a depressive phase its hard to get out of it again without the right help and the right people around you but also. Patrick has sought help and seen a therapist hes created a you tube channel called eye of patrick about enjoying life to the max what ever adversity you face he also addresses issues related to his disease. I want to talk about disability what does it mean you dont have to be in a wheelchair to be disabled its enough to have rheumatism diabetes all like me and mess. With my you tube channel i want to encourage others with that mess and tell the world that even with the disease you can still have fun. For patrick fun means high diving including cliff diving and hes going to carry on diving as long as his condition permits. Serious flare ups could mean difficulty moving or even paralysis. If you were to develop persistent coordination problems i think it would be difficult for him to continue with the sport such as high diving. Though in general sport is good for m. S. Patients it keeps them fit i would support his carrying on although he should always ask himself whether hes really up to it. But if. It can help with m. S. Patients train coordination balance and core strength. But the quality of life is also important not withdrawing into ones show. Doesnt figure so climb if its off a Little Things that help you cope i think the right friends doing sport. I come here almost every day here i am life goes on like this and magic isnt going to get you down and im not going to hide myself away its. Fine once i learn to accept things bifocal very much better just talk to you if you speak your mind be looking for if you pass out. So how are you today im fine today i like my days so if you think back for the 1st signs you had from the smile to those 2 roses what was it like what were the 1st signs oh i didnt know what happened its a long time ago its in and i think i think high for the 1st time and i started to whip blind and here im betting. They dont know what it is. This is a puzzling fort as i didnt know and so forth and i have to. Buy. Its only spinal to have that and to examine the spinal fluid in sierra missiles and that said i dont want that im sorry about it i wanted to i wanted to wait until my body felt fully what happened so you believed in your body and of the body would give you all the answers soon as i had lots of stress and was in the live and it started in 2005 that there and then 5 years yes my 3 years and i have lost my husband and in paris and i went up there over 3 it and the traffic played like pain from. Red to green and i couldnt go and this was a proper member came back to berlin and let somebody have some days later and here it was clear so finally you got your spine moved and then you got the diagnosis he had to destroy everything motleys everything changed then didnt it change that i changed my job i was there by the year later again and i said ok its fine but i will change my life either change it so isnt it very hard to get a diagnosis which will definitely change your life i think its a very very good everybody used to his normal life and then theres a complete change from one moment with the other but. For me it was great but i think that a lot of people and there are lots of property i think its better so what were your greatest fears sitting in a wheelchair for instance in the 1st time yes but later on i have the feeling feel true its not the perp and. The problem are i think its not a field trip so now youre living with multiple sclerosis there are certain kinds of attacks where the disease worsen sort of what i think. The attacks are very hard i can move a little a x. I can be armed i can. Car very much a country to i can count moves that i have and and theyre fast but normally it goes away and then i started to to live what so sharply but. I wanted to do better mastering writing i made one machine so how can you keep your good spirit oh i think my mother 1st said im a fan winning character. If you give her a push and save or make it so its in the feeling that everything will be your bank she was right i dont know much and i have this idea of the slogan from Michael Piper always on the bright side of life its very good so lets 1st take a look at what research is saying about multiple sclerosis so i will have a good talk to her face all those homes. Look times as a neurologist who researches multiple sclerosis a prelim shall he hospital hes also a medical Advisory Board member for the german m. S. I. E. He and his team are trying to find out what causes multiple sclerosis by discovering more about the triggers they hope to develop better treatment options. If this multiple sclerosis doesnt mean you will end up in. The hands of things today and why you see him is called the disease of the 1000 faces thats because the symptoms of multiple throws is very different very good the regime use military station so we have for instance. In laws we have numbness and tingling you have perries this. Sometimes also later on we have dysfunction of urine blood and later. Often fatigue is a big problem for the patients so if you take a look well divide you will find that there are approximately 2500000 cases of m. S. World wide and the number of patients increasing so why so we cannot compare the situation 40 years ago and today because a strange so many things for instance. Because advanced imaging was not available 40 years ago today is the standard. Diagnosis gnostic tool. We can make those much all years and in former years we have new. Year for diagnosis. And so also the many opportunities of treatment also increase our values for the disease so we have much more diagnosis but that does not mean that we have really more ill patients is there any explanation that occurs mainly in young people especially in women. Multiple sclerosis is a very complex disease. Mediated. Disturbance lead to destroy of tissue of the brain and spinal cord and that means. As an auto immune diseases that you have overreaction of the immune system and of course in young people theres a more potential of active immune system and the disease different here or in europe or on a global scale will divide in Different Countries yes its a very interesting question and trusting fixed all the data already showed us that there is a difference to pending from the region of patients are living that means depending from the let you would. The greater distance from the. The. Incidence of the disease so do we really know what causes multiple sclerosis. Based on the mentioned global differences different processes have been established that means for instance a series of. Exposure to sunlight and vitamin d. Plays a role in the Disease Development we have the hygiene hypothesis. Which means that the development of the immune system in the child needs some challenges which we dont have in this amount in developed countries but if there are so many different causes and be perhaps dont know them all and how can we treat this. We dont treat the causes of them as we try to. Stops. Just. Over activity and so we have to do. About 16 different drugs approved during the last 25 years and they are very different from if you can see from the side effects from the application of you have injectable so you have oral drugs infusions and so we can try for every individual patients the best. Treatment. Our aim is to reach the socalled. That means no evidence of disease activity so if we speak about the immune system really have to take a look at our gut flora of the big tyria in our intestines because they play an Important Role for immune system even in a mess patients. Happy cut may be the key to health in particular the health of the brain new Research Shows that the brain gut axis plays a significant role in diseases like Parkinsons Alzheimers and multiple sclerosis. Into order for your brain to function normally an intact gastrointestinal system with healthy intestinal flora is crucial the intestines feed the brain the new discoveries are coming so fast that im certain will no longer be able to ignore the gut when it comes to therapies for diseases. Recent studies show that the bacteria in our intestines are of more importance than previously believed billions of microorganisms live in our gut around 2 kilograms worth and they affect our brain 2. Studies on mice have shown that eliminating intestinal flora can damage brain activity. Weve found that when mice have a flawed gastrointestinal system with no gut bacteria the immune system in the brain is dramatically affected in these. Researchers at the university of Medical Center took a close look at immune cells the protect the brain against disease they discovered that these cells only function if intestinal bacteria can produce certain substances that they need. The mother wasnt easy usually visa immune cells called micro gliomas cells are very active in the brain they have small appendages which monitor the nerve cells of the Central Nervous system if bacterial metabolites short chain fatty acids disappear then viz immune cells are hampered they wither away like plants in a garden that are not watered. The brains immune system atrophies when it doesnt get certain materials from the gut. Intestinal bacteria are responsible for turning the food we eat into valuable substances among them short chain fatty acids. Acid. Scientists wanted to know if these fatty acids could in turn cure a disease brain they tested this by adding probably on the catheter the Drinking Water of a sick mind the result the immune system recovered. Thats fine for you it was a completely surprising finding we didnt expect it at all. Would it also be the same case in humans would it be possible to heal the brain via the gut doctors that fun to use of hospital and think so you know. Theyve seen that the brain as well as the intestines are affected in patients with multiple sclerosis. Is in an affair and move on the computer and weve observed a change in the composition of the intestinal microbiome that means all of the bacterial strains that exist within the intestines and what were seeing is in effect an impoverished not a decline and diversities of bacterial species in my gut dom among the hundreds of bacterial species found in our guts about 160. 00 appeared to be common to the Healthy Human intestine people with m. S. Some of those are missing for reasons that arent entirely clear and that leads to a deficit of short chain fatty acids such as propane acid. Because there are fewer bacteria present less probiotic acid is developed in the intestine and thats reflected in the patients blood group you know. That also proved true for an order who has an ass she had unusually low levels of probiotic acid in her blood. The doctor decided to add appropriate supplement to her other medication and it appears to help york so does this mean i coughed i have more strength its easier for me to complete my daily activities i also feel more focused in mice but in most patients say that after a short period of time they already noticed an improvement they feel more fit they have more strength experience less fatigue. And theyre less susceptible to infections veining fact unfairly but the main change could be measured in their blood the doctors found that immune cells increased by 30 percent and the number of certain white blood cells implicated in inflammation drops by up to 50 percent ariano coleman must also given probiotic acid and not only did the symptoms of m. S. Improve another condition did as well. As the health of fata tappet i was waiting for my hay fever symptoms to appear but they didnt and then i realized that it could have to do with the probiotic acid that i took. The hypothesis is that part of the immune system is located in the intestinal walls immune cells as well as bacteria and their metabolic products are all found there and the fatty acids that the bacteria produce could be what strengthening the immune system. Neurologist god is convinced that thats the case hes a multiple sclerosis specialist he says he hasnt found any negative side effects from propane on a gas at some quantities we dont know of any risks and the European FoodSafety Authority has cleared an amount that is actually 200. 00 times higher than the concentration endos that we consider useful. Binyamin when patients ask me i say try it out and see if it works for you i have to emphasize again and again that we dont have data from Clinical Trials and county commission. Therapies are still being researched but one thing is for sure healthy balanced diet benefits here intestinal flora will make your gut feel good and maybe help your brain as well. As whats your take on property and i guess it. Well we are often from our patients take probably want to guess it but is it probably on a guess that as a short chain fatty acids produced by special bacteria in the gut and we know that this probably want to get as it is influencing special immune cells from the Animal Studies we know that it has an effect and so we hope its also the fictive in patients is the treatment of as patients as additional treatment but theres a lack of larger studies still that there are no major side effects so you could just try it. If Patients Want to say ok i take it because it has no side effects and what about vitamin d. I mean there are several studies suggesting that this might be helpful in the mist patients. Yes. We know that from other studies too and also in our patients we look for it to be delivered as a blot and the most of the patients really have a very low vitamin d. Level so we. Give them a supplement of vitamin d. And the most neurologists are doing that but you dont know except if it really influence the course of the disease so what else can patient to say nutrition wise response and exercise. First of all as a physician to comment that there should be that issue takes a prescribed medication but they can do a lot of. If you talk about that. We meant the show to perform insurance sports that means walking jogging swimming or cycling. As they can and should not smoke because smoke this lead to a progression of multiple sclerosis so if a patient today would get the diagnosis multiple sclerosis what are his chances to stay out of a wheelchair in the past is evidence that. Shorter life span a little bit but you have known you are data. Concerning the modern treatment and. Hope for the modern treatment. Enabled the patient to lead a normal life or a good life. Even visit. Thank you so much for this talk today and i know this is a very very interesting show and you dont want to leave your t. V. Screen but you have to if you want to write us an email. In good shape issue Weekly Health show on d w covering many aspects of health care we look at whats new in medical treatment nutrition fitness and beauty. We discuss these topics in depth with specialists and offer you opportunities to pose your own questions. On an upcoming show well be talking about antibiotics theyre being prescribed more often than ever but resistance is also on the rise what are the consequences and are there alternatives send your questions to in good shape at d w dot com just write the word antibiotics in the subject line we look forward to hearing from you. So how do you see a future i appeared at the computer open and i like it and i lie. Dont mess for ever think whats coming out there and he wishes now lots of. I want hope for everybody i want that people are respecting everybody. I think its very important for college and lets check in here very important issues lets hope that they get true. So see you again next week and im so then lets all try to stay in good shape. After. Days. Of t. V. Robotics. Deep learning merge to reality wait a 2nd we want the whole picture our facts instead of vague ideas of shifts deliver us. From a measure to reality to cryptocurrency your topics for live in an ever changing Digital World lets start to devise a similar. Shift. On d w. I thought her. Culture. Hair. Color superman. Superfood stylish style icon to let os. Life style during. The lomax 90 minutes on w. Im scared that if i work thats hard and in the end its a me youre not a lot of the year and we will send you back. Are you familiar with this. With the smugglers were alliance of. Whats your story ready. Im with i was a women especially in victims of violence. Take part and send us your story we are trying always to understand this new culture. Another visitor another yes you want to become a citizen. In for migrants your platform for reliable information. 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