Dual-Ligand-Modified Liposomes for Inhibiting Metastasis

In vitro Cytotoxicity Assays
Tumor angiogenesis promotes HCC development and metastasis. To investigate the in vitro cytotoxicity of different drug formulations, both MTT and Live/Dead assay were carried out on two-level cell culture systems (Figure 4C,
Supporting Figure 1): BEL7402 cells alone or BEL7402/HUVEC co-cultured cells. As shown in Figure 4Dand E, all drug treatment groups showed concentration-dependent cytotoxicity against BEL7402 cells and co-cultured system. Meanwhile, the CUCA/GA&Gal-Lip exhibited higher toxicity than CUCA/Lip and CUCA/Gal-Lip. It might be attributed to the stronger liver-targeting capability of dual-ligand-modified Lip, which was shown in the cellular uptake analysis (Figure 3). Interestingly, the IC

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Japan ,China ,Beijing ,United States ,Weifang ,Shandong ,Ruixi ,Hainan ,Jintan ,Anhui ,Malvern Zetasizer Nano ,Xian Ruixi Biological Technology Co Ltd ,Biotechnology Research Institute ,Jinan Pengyue Lab ,Preparation Of Co ,Aladdin Chemistry Co ,Innochem Co Ltd ,Aladdin Chemistry ,Animal Experiment Ethics Committees ,Weifang Medical University ,Animal Management Rules ,Co Loaded Lip Modified ,Drug Release ,Metastasis Model ,Various Liposomal ,Gal Modified Lip ,ஜப்பான் ,சீனா ,பெய்ஜிங் ,ஒன்றுபட்டது மாநிலங்களில் ,சாண்டோங் ,ஹைனன் ,ஜிந்தன் ,அன்ஹுய் ,உயிரி தொழில்நுட்பவியல் ஆராய்ச்சி நிறுவனம் ,விலங்கு மேலாண்மை விதிகள் ,மருந்து வெளியீடு ,