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Glycated hemoglobin (HbA1c) could have prognostic value for people without diabetes and no history of cardiovascular disease (CVD), according to an observational study of nearly 4,000 middle-age individuals.
In the PESA study, HbA1c showed a graded, positive association with the prevalence and multi-territorial extent of subclinical atherosclerosis detected by vascular ultrasound and noncontrast cardiac CT, reported Valentin Fuster, MD, PhD, of the Icahn School of Medicine at Mount Sinai in New York City and Centro Nacional de Investigaciones Cardiovasculares Carlos III in Madrid, and colleagues.
This association was independent of traditional cardiovascular risk factors and was significant in all prediabetes groups, even below the prediabetes cutoff (HbA1c 5.5%-5.6%; OR 1.36, 95% CI 1.03-1.80,