the future only happens with people who really know how to deliver it. bipolar i disorder can make you feel like you have no limits. but mania, such as unusual changes in your mood, activity or energy levels, can leave you on... shaky ground. help take control by asking your healthcare provider about vraylar. vraylar treats acute mania of bipolar i disorder. vraylar significantly reduces overall manic symptoms, and was proven in adults with mixed episodes who have both mania and depression. vraylar should not be used in elderly patients with dementia, due to increased risk of death or stroke. call your doctor about fever, stiff muscles, or confusion, which may mean a life-threatening reaction or uncontrollable muscle movements, which may be permanent. side effects may not appear for several weeks. high cholesterol and weight gain; high blood sugar, which can lead to coma or death; decreased white blood cells, which can be fatal; dizziness upon standing; falls; seizures; impaired judgement; heat sensitivity; and trouble swallowing may occur.