previously treated withd noplatinum-based chemotherapy, including those with an abnormal alk or egfr gene who've tried an fda-approved targeted therapy, this is big. a chance to live longer with opdivo (nivolumab). opdivo demonstrated longer life and is the most prescribed immunotherapy for these patients. opdivo significantly increased the chance of living longer versus chemotherapy. opdivo works with your immune system. opdivo can cause your immune system to attack normal organs and tissues in your body and affect how they work. this may happen any time during or after treatment has ended, and may become serious and lead to death. see your doctor right away if you experience new or worsening cough; chest pain; shortness of breath; diarrhea; severe stomach pain or tenderness; severe nausea or vomiting; extreme fatigue; constipation; excessive thirst or urine; swollen ankles; loss of appetite;