cairo. 400 injured and at least one killed. mubarak supporters sealed off the main square and trapping the opposition inside. >> it is my belief that an orderly transition must be meaningful, it must be peaceful, and it must begin now. >> former u.s. bread nicholas burns, professor at hard harvard school joins us. you know our point person and ambassador on the ground. what is wisner likely telling mubarak and those around mubarak who are listening to the united states? isn't he being told that his time is up? >> well, andrea, what a disastrous day for all egyptians and u.s. policy toward egypt.