taking plavix alone or with some other medicines, including aspirin, may increase bleeding risk, which can potentially be life threatening, so tell your doctor when planning surgery. tell your doctor all medicines you take, including aspirin, especially if you've had a stroke. if fever, unexplained weakness or confusion develops, tell your doctor promptly. these may be signs of ttp, a re but potentially life-threatening condition, reported sometimes less than two weeks after starting plavix.