it may cause severe diarrhea, nausea, or vomiting. otezla is associated with an increased risk of depression. tell your doctor if you have a history of depression or suicidal thoughts or if these feelings develop. some people taking otezla reported weight loss. your doctor should monitor your weight and may stop treatment. upper respiratory tract infection and headache may occur. tell your doctor about your medicines and if you're pregnant or planning to be. ready to treat differently with a pill? otezla. show more of you. what! she's zip lining with little jon? it's lil jon. even he knows that. thanks, captain obvious. don't hate-like their trip, book yours with hotels.com and get rewarded basically everywhere. hotels.com. be there. do that. get rewarded. do your asthma symptoms ever hold you back? about 50% of people with severe asthma have too many cells called eosinophils in their lungs. eosinophils are a key cause of severe asthma.