increased risk of bleeding or bruising may occur, especially if taken with nsaid pain relievers, aspirin or blood thinners. manic episodes or vision problems may occur in some people. may cause low sodium levels. the most common side effects were nausea, constipation and vomiting. trintellix had no significant impact on weight in clinical trials. ask your healthcare professional about trintellix. (avo)it off with contrave. it's fda-approved to help adults who are overweight or struggle with obesity. contrave is believed to work on two areas of the brain: your hunger center... i'm so hungry. (avo) to reduce hunger. and your reward system... ice cream. french fries. (avo) to help control cravings. one ingredient in contrave may increase suicidal thoughts or actions in some children, teens, and young adults in the first few months. serious side effects are mood changes like depression and mania, seizures, increased blood pressure or heart rate, liver damage, glaucoma, allergic reactions and hypoglycemia.