Adults aged 18 and over can now receive a Covid-19 vaccine.
Bookings opened from 8am today, 27 May.
Vaccine supplies remain limited and as a result there will be approximately 20,000 slots available for booking on Thursday morning.
Health Minister Robin Swann said: "I am delighted that our vaccination programme is now open to all adults in Northern Ireland.
"I know this will be very welcome news for young people who have been waiting patiently for their turn to get the jab.
"Today's announcement is another important milestone in the drive to get as many people vaccinated as quickly as we can, so that we can see a return to normality.