Oxford Bus Company revealed that Blue Skye Thinking as the winner of Brand the Bus.
The charity will now be invited to work with the company to design a bus wrap featuring the brand colours, logo and messages of the organisation.
The winner was selected by a judging panel from a top ten group of good causes which had earned the most public votes from 23 original entries.
Blue Skye Thinking supports treatment and research into childhood brain tumours.
It was set up by Abingdon-based couple Sally and Andrew Hall in the honour of their son who passed away aged five because of complications in his treatment for a brain tumour.