<p>To overcome both the risks of immune rejection and of potential tumor formation during cell and organ transplants, researchers Baoyang Hu and colleagues from the <a href="https://www.cas.cn/" target="_blank">Chinese Academy of Sciences</a>, Beijing, have genetically engineered stem cells so that liver cells obtained from them would be invisible to the immune system. At the same time, immature, potentially tumorigenic stem cells would still be attacked and eliminated by the immune system. Similar approaches could be used to protect other stem cell-derived tissues, such as heart cells or pancreatic cells, from immune rejection. The research published today in <a href="http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(23)00418-6" target="_blank"><em>Stem Cell Reports</em></a>. The safety and efficacy of those stem cell-derived transplants will require further validation in pre-clinical and clinical studies. </p>