Thames Water and Swindon Borough Council are fixing the leak.
An SBC spokesman said: "We have been forced to close Commercial Road due to a burst water main.
"Thames Water are on the scene to fix the problem.
"We will reopen the road as soon as we are able."
A Swindon Police spokesman said: "Due to what appears to be a burst water pipe, Commercial Road is currently closed to vehicles up to and including Newhall Street.
"Thames Water and Swindon Borough Council are on scene and the road is being assessed to see if there is any under surface damage before it can be re-opened.